Artigos
High-resolution structure of hair-cell tip links
Proc Natl Acad Sci U S A. 2000 Nov 21;97(24):13336-41. Kachar B(1), Parakkal M, Kurc M, Zhao Y, Gillespie PG.
Transduction-channel gating by hair cells apparently requires a gating spring, an elastic element that transmits force to the channels. To determine whether the gating spring is the tip link, a filament interconnecting....
Structural basis for mechanical transduction in the frog vestibular sensory apparatus: III. The organization of the otoconial mass
Hear Res. 1999 May;131(1-2):11-21. Kurc M(1), Farina M, Lins U, Kachar B.
The saccule and the utricle of the vestibular system detect linear acceleration and gravity. Sensory transduction in these organs depends on myriads of calcium carbonate crystals of high specific...
ATP-Induced Ca2! Release in Cochlear Outer Hair Cells: Localization of an Inositol Triphosphate-Gated Ca2! Store to the Base of the Sensory Hair Bundle
J Neurosci. 1999 Aug 15;19(16):6918-29. Mammano F(1), Frolenkov GI, Lagostena L, Belyantseva IA, Kurc M, Dodane V, Colavita A, Kachar B.
We used a high-performance fluorescence imaging system to visualize rapid changes in intracellular free Ca2+ concentration ([Ca2+]I) evoked by focal applications of extracellular ATP ....
Cochlear outer hair cell electromotility can provide force for both low and high intensity distortion product otoacoustic emissions
Hear Res. 1998 Dec;126(1-2):67-74. Frolenkov GI(1), Belyantseva IA, Kurc M, Mastroianni MA, Kachar B.
It was proposed ¢fty years ago that the extraordinary sensitivity and the frequency selectivity of the mammalian hearing depend on a cycle-by-cycle ampli¢cation of sound-induced vibrations in the organ of Corti (Gold, 1948). It is a ...
The Otoconia of the Guinea Pig Utricle: Internal Structure, Surface Exposure, and Interactions with the Filament Matrix
J Struct Biol. 2000 Jul;131(1):67-78. Lins U(1), Farina M, Kurc M, Riordan G, Thalmann R, Thalmann I, Kachar B.
A unique feature of the vertebrate gravity receptor organs, the saccule and utricle, is the mass of biomineral structures, the otoconia, overlying a gelatinous matrix also called “otoconial membrane” on the surface of the sensory epithelium...
Screening for the GJB2 c.-3170 G>A (IVS1+1 G>A) mutation in Brazilian deaf individuals using multiplexligation-dependent probe amplification
Genet Test Mol Biomarkers. 2009 Oct;13(5):701-4. da Silva-Costa SM(1), Coeli FB, Lincoln-de-Carvalho CR, Marques-de-Faria AP, Kurc M, Pereira T, Pomilio MC, Sartorato EL.
Mutations in GJB2 gene are the most common cause of nonsyndromic sensorineural recessive hearing loss. One specific mutation, c.35delG, is the most frequent in the majority of Caucasian populations and may account for up to ...
Dr. Mauricio Kurc publicou mais de 20 artigos, em diversas áreas da otologia, otoneurologia, diagnóstico e reabilitação da perda auditiva, surdez genética, implantes cocleares, emissões otoacústicas, fisiologia da audição, cóclea, rinologia, laringologia, ronco e apnéia do sono